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Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines

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1 Cait J., Hughes M.R., Zeglinski M.R., Chan A.W., Osterhof S., Scott R.W., Hernaez D.C., Cait A., Vogl W., Bernatchez P., Underhill T.M., Granville D.J., Murphy T.H., Roskelley C.D

This ERK-without-Akt profile supports cellular proliferation and survival while maintaining cells in a proliferative rather than differentiated state contrasting sharply with IGF-1s PI3K/Akt/mTOR-dominant signalling, which drives protein synthesis and differentiation

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